Osteopontin and lung cancer
- VernacularTitle:骨桥蛋白与肺癌
- Author:
Jiongyi WANG
;
Bin JIANG
- Publication Type:Journal Article
- Keywords:
Osteopontin;
Lung neoplasms
- From:
Cancer Research and Clinic
2008;20(7):499-502
- CountryChina
- Language:Chinese
-
Abstract:
Osteopontin (OPN), a phospborylated and glycosylated protein,is a prominent matrices component of the extracellular matrix of mineralized tissues of bones and teeth, in which they can regulate the formation and growth of hydroxyapatite crystals and influence a variety of cell activities.Recent studies have reported that the expression of OPN is not only correlated with bone formation and bone resorption but also with tumor aggression and metastasis in several types of human cancer,and OPN is even considered to be an index for the diagnosis and prognosis of tumor.This article reviews OPN's role in lung cancer' s infiltration, metastasis and prognosis.
