PARP-1, CK7/20 and p53 in Barrett's esophagus and esophageal adenoeareinoma: expression and its significance
- VernacularTitle:PARP-1、CK7/20和p53在Barrett食管和食管腺癌中的表达及意义
- Author:
Han WU
;
Chenggong YU
;
Lihua ZHANG
;
Qin HUANG
;
Xiaoping ZOU
- Publication Type:Journal Article
- Keywords:
Barrett esophagus;
Adenoearcinoma;
Diagnosis
- From:
Chinese Journal of Digestive Endoscopy
2008;25(6):304-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of poly (ADP-ribose) polymerase-1 (PARP-1 ), cytokeratins (CK) 7/20, and p53 in patients with Barrett's esophagus and esophageal adenocareinoma,and to evaluate their significance. Methods Expression of PARP-1, CK7/20 and p53 were determined by immunohistochemistry in 108 patients (including 40 Barrett's esophagus, 28 esophageal adenocarcinoma and 40 cardiac mucosa). Results The expression of PARP-1 was found in Barrett's esophagus, esophageal ade-nocarcinoma and cardiac epithelium with a significantly higher level in esophageal adenocarcinoma than the other two groups (P <0. 01 ). CK7/20 was expressed in much of intestinal metaplasia, part of cardiac epi-thelium and adenocarcinoma cells. The positive expression of p53 was observed in all three groups, and it was significantly higher in adenocarcinoma group than in other two groups (P < 0. 05 ). PARP-1 expression is highly correlated with that of p53 in Barrett's esophagus ( r= 0.49, P < 0.01 ). Conclusion CK7/20 is a sensitive but less specific indicator for intestinal metaplasia. Both PARP-1 and p53 are involved in the patho-genesis of esophageal adenocarcinoma and might help to determine the risk of Barrett's esophagus developing into esophageal adenocarcinoma.
