Preliminary study on relationship between gene polymorphisms of interleukin-23 receptor and inflammatory bowel disease
- VernacularTitle:白细胞介素-23受体基因多态性与炎症性肠病关系的初步研究
- Author:
Zhengyan CHEN
;
Fachao ZHI
;
Jia ZHI
;
Guopeng YAO
;
Yong LIN
;
Jing GUAN
;
Yingchun ZHANG
;
Jide WANG
;
Ye CHEN
;
Bo JIANG
- Publication Type:Journal Article
- Keywords:
Interleukin-23 receptor;
human;
Genetic polymorphisms:Inflammatory bowel diseases
- From:
Chinese Journal of Digestion
2008;28(6):369-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of two single nuclear peptides(SNPs)polymorphisms(rs11209026 and rs11805303)which lies in interleukin-23 receptor(IL23R)gene with susceptibility to inflammatory bowel disease(IBD).Methods The target SNPs were directly sequenced by polymerase chain reaction(PCR)and gene polymorphisms of 50 healthy and 81 patients with IBD (Crohn's disease in 41 patients and ulcerative colitis in 40 patients)were analyzed using chromassoftware.Results The geno-type frequency and allelic frequency of rs11209026 were 7.3%and 3.7%in patients with Crohn's disease respectively,15.0%and 7.5%in patients with ulcerative colitis respectively as well as 14.0%and 7.0%in normal population respectively(all P value＞0.05).The geno-type frequency and allelic frequency of rs11805303 were 22.0%and 52.4%in patients with Crohn's disease respectively,15.0% and 41.2% in patients with ulcerative colitis respectively as well as 34.0%and 59.0%in normal population respectively(all P value＞0.05).But in allelic frequency there was significant difference between ulcerative colitis patients and normal population(P=0.018).The polymorphisms of rs11805303 loci did not correlate with age,gender,disease duration.activity and site in patients with ulcerative colitis.Conclusions IL23R gene polymorphism is not associated with the susceptibility to Crohn's disease.rs11805303 allele may be related with susceptibility to ulcerative colitis.But no correlation was found between the SNP polymorphisms and the clinical characteristic of ulcerative colitis.
