Correlation between the HLA-A, B alleles polymorphism and hemorrhagic fever with renal syndrome of Han nationality in Zunyi area
- VernacularTitle:HLA-A、B基因多态性与遵义地区汉族人群肾综合征出血热的相关性研究
- Author:
Junmin LUO
;
Wanbang SUN
;
Xuegui HUANG
;
Weihong LI
;
Yixiong ZHANG
;
Mingying SONG
;
Xinsheng YAO
- Publication Type:Journal Article
- Keywords:
HLA-A;
B gene;
Hemorrhagic fever with renal syndrome (HFRS);
Correlation
- From:
Chinese Journal of Microbiology and Immunology
2008;28(6):499-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between HLA-A, B alleles polymorphism and hemorrhagic fever with renal syndrome (HFRS) among Han nationality in Zunyi area. Methods Using group study, HLA-A, B genotypes were conducted in 100 HFRS cases and 100 controls among Han nationality in Zunyi area with polymerase chain reaction-sequence specific primer (PCR-SSP), gene frequency (GF) and relative risk (RR) were compared and calculated. Results The frequencies of HLA-A * 31 and HLA-B * 58 alleles in HFRS cases (GF=4%,12.5%) were strikingly higher than that in the healthy controls (X2=6.380, 7.792, P<0.05;RR=18.47,2.91). The frequencies of HLA-B * 40 alleles in HFRS cases (GF=11%) were strikingly higher than that in the healthy controls (X2=6.095,P<0.01, RR=O.47). Conclusion HLA-A * 31, B * 58 genes are positively related to HFRS of Han nationality in Zunyi area, HLA-B * 40 gene is negatively related to HFRS of Han nationality in Zunyi area.
