Changes in Insulin-like growth factor-1 levels in the brains and livers of rats after cerebral ischemic injury
- VernacularTitle:局灶性脑缺血大鼠胰岛素样生长因子-1在脑和肝脏中的变化
- Author:
Chuan LI
;
Jianzhong FAN
;
Hongying WU
;
Yi WEI
- Publication Type:Journal Article
- Keywords:
Focal cerebral ischemia;
Rats;
IGF-1
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(8):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe dynamically the expression of insulin-like growth factor(IGF-1)in the brain and liver,and to explore changes in IGF-1 levels.Methods The thread method waa used to establish middle cerebral artery occlusion in rats.The expression of IGF-1 on the ischemic side of the cerebral cortex and in the liver wag observed dynamically using immunohistochemical techniques. Results The number of IGF-1-positive cells increased significantly,peaking on the 3rd day in the cortex and the 7th day in the liver.Conclusion The expression of IGF-1 Wag upregulated in the brain after the experimental cerebral ischemia;peripheral humoral regulation of IGF-1 responded more slowly and recovered to some extent at the 7th day after cerebral ischemia.
