Expression of α1-AT and VIEGF-C in human bronchoalveolar carcinoma
- VernacularTitle:α1-AT、VEGF-C在细支气管肺泡癌的表达
- Author:
Jie ZHOU
;
Fangyun XU
;
Qiong FENG
;
Yijun LIU
;
Xiao LUO
- Publication Type:Journal Article
- Keywords:
Bronchoalveolar carcinoma;
α1-AT;
VEGF-C;
Lymph nodal metastasis;
Immunohistochemical SP method
- From:
Cancer Research and Clinic
2008;20(8):542-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of α1-AT and VEGF-C in human bronchoalveolarcarcinorrm, and the relation of the expression to the patholo~cM differentiation and clinical stage. Methods All 49 Darffin embedding samples of patients with bronchoalveolar carcinoma were studied. α1-AT and VEGF-C were detected by immunohistochemical SP method.Automated image analyzer was used to quantify α1-AT and VEGF-C expressions.Results The immunohistochemical positive stainings of α1-AT and VEGF-C in brown or dark brown were located in cytopla8m.The expression levels of α1-AT and VEGF-C were not related with the gender,age,tumor position and size,and histology subtypos(P＞0.05).It Was found that the expression of α1-AT in patients with local lymph node metastasis was significantly lower than those without node metastasis(P＜0.001).It was found that the expression of VEGF-C in patients with local node metastasis significantly higher than th08e without node metastasis(P＜0.001).There Was a negative correlation between the expression level of α1-AT and the expression level of VEGF-C in bronchoalveolar carcinoma(r=-0.324,P＜0.05).Conclusion α1-AT and VEGF-C could be secreted by bronehoalveolar carcinoma.Bronehoalveolar carcinoma with lower α1-AT expression and higher VEGF-C expression is more likely to have lymph node metastasis.Lower α1-AT expression and higher VEGF-C expression can participate in the mechanism of lymph node metastasis in carcinoma together.
