HLA-DRB1 genotyping in children with nephrotic syndrome of non-IgA mesangial proliferative giomerulonephritis
- VernacularTitle:病理为非IgA系膜增生性肾小球肾炎的小儿肾病综合征HLA-DRB1基因分型
- Author:
Tao LAN
;
Aimei GAO
;
Demei ZHANG
;
Yan LIU
;
Yunxia JIA
;
Junsong JIA
- Publication Type:Journal Article
- Keywords:
HLA-DRB1 alleles;
Nephrotic syndrome;
Non-IgA mesangial proliferative glomerulo-nephritis;
PCR-SSP
- From:
Chinese Journal of Microbiology and Immunology
2008;28(7):647-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of HLA-DRB1 alleles in Han population of Shanxi childrcn with nephrotic syndrome of non-IgA mesangial proliferative glomerulonephritis (MsPGN). Methods HLA-DRB1 was performed by polymerase chain reaction-sequence specific primers technique, and twenty patients with nephrotic syndrome of non-IgA MsPGN were detected. Results Analysis of the fre- quencies of specific at the HLA-DRB1 loci revealed significantly higher frequencies of HLA-DRB1 * 11 al- leles among the nephrotic syndrome patients of non-IgA MsPGN comparing with controls (22. 50% vs 8.33%, x2= 9. 544, P = 0.002, CI = 1. 674-9.995, RR = 4.09). Nine patients with HLA-DRB1 * 11 all accompanied hematuria, hypertension or short renal insufficiency. Conclusion The results suggested that HLA-DRB1 * 11 alleles contribute to genetic susceptibility to nephritic syndrome of non-IgA MsPGN. The pa- tients with HLA-DRB1 *11 easy accompanied hematuria, hypertension or short renal insufficiency.
