Update on sublingual immunotherapy in patients with asthma due to house-dust mites
10.3760/cma.j.issn.1673-4408.2011.01.020
- VernacularTitle:尘螨过敏性支气管哮喘的舌下免疫治疗研究进展
- Author:
Zhen ZHOU
- Publication Type:Journal Article
- Keywords:
Asthma;
House dust mite;
Sublingual immunotherapy
- From:
International Journal of Pediatrics
2011;38(1):56-58
- CountryChina
- Language:Chinese
-
Abstract:
Sublingual immunotherapy(SLIT) has received increasing attention as a treatment for asthma due to house-dust mites. The precise mechanisms of SLIT remain unclear, but SLIT has been shown to modify the balance of Th1/Th2, increase IgG4 and decrease IgE. The allergen is captured within the oral mucosa by Langerhans-like dentritic cells, suggesting that such cells are prone to induce tolerance. Increasing data support the safety, efficacy and good compliance with SLIT. However, the precise mechanisms, optimal dosage and duration of SLIT require further investigation.
