Relationship between gene polymorphisms of coagulation factor Ⅶ and ischemic cerebrovascular diseases in Henan Han population
10.3760/cma.j.issn.1006-7876.2011.02.006
- VernacularTitle:凝血因子Ⅶ基因多态性及其单倍型与缺血性脑血管病的相关性
- Author:
Ying HE
;
Qingchuan FENG
;
Haidong YU
;
Junyu BAI
;
Hua QI
;
Hong ZHENG
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Cerebrovascular disorders;
Factor Ⅶ;
Polymorphism,genetic;
Haplotypes
- From:
Chinese Journal of Neurology
2011;44(2):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the associations between coagulation factor Ⅶ (FⅦ)polymorphisms and its haplotype with risk of ischemic cerebrovascular diseases (ICVD) in Henan Han population. Methods Five hundred and twelve cases with ICVD as patient group and 560 healthy subjects as control were recruited in the study. The polymorphisms of R353Q, 5'F7 and IVS7 were detected by PCR-RFLP. The genotype frequency and allele gene frequency were compared between ICVD group and control group. The haplotype was analyzed by SHEsis software. Results The RQ genotype frequencies and Q allele frequencies of ICVD group were significantly lower than those of control group. The distribution of H7 allele frequencies and H6H7 genotype frequencies of FⅦ/IVS7 polymorphisms had significant difference between ICVD group and control group. Finally, the prevalence of R-P0-H6 haplotype in ICVD group(53. 3% )was higher than that in control group (47.5%, OR = 1. 219, 95% CI 1. 028-1. 446,P =0.023). Conclusions In Henan Han population, the Q allele of F Ⅶ/R353Q polymorphisms and the H7 allele of F Ⅶ/IVS7 polymorphisms may be protective genetic factors against ischemic cerebrovascular disease, and the R-P0-H6 haplotype may be a risk factor of ischemic cerebrovascular disease.
