The evolution and dissemination of macrolide-resistance Streptococcus pneumoniae in Shanghai
- VernacularTitle:上海地区大环内酯类抗生素耐药肺炎链球菌的遗传学分析
- Author:
Wenjuan WU
;
Xiaofei JIANG
;
Hong ZHANG
;
Fupin HU
;
Lizhong HAN
;
Demei ZHU
;
Yuxing NI
- Publication Type:Journal Article
- Keywords:
Streptococcus pneumoniae;
Macrolides;
Drug resistance,bacterial;
Evolution,molecular
- From:
Chinese Journal of Laboratory Medicine
2008;31(10):1124-1127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the genetic background and evolutional route of macrolideresistance Streptococcus pneumoniae(MRSP)strains in Shanghai.Methods Forty-seven MRSP clinical isolates were genotyped by pulse field gel electrophoresis(PFGE)to detect the donal relationship of therm.Serotyping and muhilocus sequence typing(MIST)on 6 multi-resistant strains wag used to investigate the evolutional relationship between serum types and international epidemic strain among MRSP strains in Shanghai.Results There were 2 epidemical clones(type A 45%,type B 17%)in MRSP clinical isolates containing both the ermB and the mefE genes in Shanghai.MIST analysis showed that all 6 multi-resistant strains whose PFGE pattern was A type belonging to Asia clonal complex-CC236(Taiwan19F-14 clone).There was a novel ST-ST2116,which might derived from CC236 due to the recombination with alldic change.Conclusion,The high prevalence of erythromycin-resistant Streptococcus pneumoniae containing both the ermB and the mere genes in Shanghai is partly due to the clonal spread of a few mtdtidrng-resistant clones.
