The therapeutic effect of thalidomide on gastrointestinal bleeding of angiodysplasia:an observational study
- VernacularTitle:沙利度胺治疗血管发育不良所致消化道出血的疗效观察
- Author:
Chunhong XU
;
Zhizheng GE
;
Wewzhong LIU
;
Haiying CHEN
;
Yunjie GAO
;
Huimin CHEN
;
Yunbiao HU
;
Shudong XIAO
- Publication Type:Journal Article
- Keywords:
Gastrointestinal hemorrhage;
Thalidomide;
Angiodysplasia;
Therapy
- From:
Chinese Journal of Digestion
2008;28(8):547-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and investigate the therapeutic effect of thalidomide on gastrointestinal bleeding of angiodysplasia.Methods Eighteen patients with recurrent gastrointestinal bleeding of angiodysplasia were treated with thalidomide 100 mg daily for 4 months.Median follow-up time was 16.7 months.The changes of clinical setting and serum.vascular endothelial growth factor(VEGF)and tumor necrosis faetor-α(TNF-α)level between pre-therapy and post-therapy were compared.Results The clinical setting of patients in post therapy was significantly better than that in pre-therapy.The overall symptom score,the median bleeding frequency and median transfusion volume of patients after therapy was significantly lower than those before the therapy[(15.000±3.630)vs(5.330±3.325),(11.220±6.404)vs(1.000±1.237),(1422.22±1556.601)ml vs(100.00±240.098)ml,respectively,all P＜0.01],while median hemoglobin was obviously higher than that before the therapy[(5.950±1.656)g/ml vs(9.533±2.278)g/ml,P＜0.01].Serum VEGF and TNF-α levels decreased obviously after the therapy(118 pg/ml vs 58 pg/ml,116 pg/ml vs 34 pg/ml,P＜0.01).Conclusions Thalidomide can suppress the serum VEGF and TNF-α levels of the patients with recurrent gastrointestinal bleeding of angiodysplasia,then play a significantly role in preventing the rebleeding in patients with recurrent gastrointestinal bleeding of angiodysplasia.
