Strengthening investigation and monitoring on drug resistance of hepatitis B virus
- VernacularTitle:加强HBV耐药的认识和监测
- Author:
Jun CHENG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Drug resistance,viral;
Mutation
- From:
Chinese Journal of Laboratory Medicine
2008;31(8):849-851
- CountryChina
- Language:Chinese
-
Abstract:
Antiviral therapy is important for patients with chronic hepatitis B. Mutation of hepatitis B virus ( HBV ) is closely related to drug resistance of HBV. Immune selection and drug treatment have effects on emergence of drug resistance. Polymerase chain reaction based techniques are major methods for detection of drug resistance of HBV. Regular detection of HBV DNA is the most important method for monitoring drug resistance. Combination therapy of lamivudine plus adefovir is superior to adefovir alone for lamivudine-refractory patients with chronic hepatitis B.
