Early dynamic changes of liver function and its prognostic implications after therapy of interventional radiology for hepatocenular carcinoma
- VernacularTitle:肝癌患者介入治疗后早期肝功能动态变化对预后的价值
- Author:
Mingtao SU
;
Shaobing DING
;
Huiyu QIU
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Radiology,interventional;
Prognosis
- From:
Cancer Research and Clinic
2008;20(9):607-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of liver function and its clinical significance during the treatment of hepatocellular carcinoma by hepatic arterial and segmental arterial embolization. Methods Hepatic arterial embolization (conventional LP-TAE) was performed in 52 cases of hepatocellular carcinoma and segmental arterial embolizational(segmental LP-TAE) was done in 33 cases. The main data of the change of liver function were reviewed in three days and six months after treatment. All cases were followed up for 1 to 5 years. Results The change of ALT, AST, ALP, TBIL in conventional LP-TAE were remarkably increased than that in segmental LP-TAE after three days (P=0.000). After six months by LP-TAE, the Child of liver function in segmental group decreased obviously lighter than that in conventional group (P=0.000). The survival rates at 1-, 3-, and 5-year were 90.9%, 60.6% and 30.3% in segmental LP-TAE, respectively, and 61.5%, 21.2% and 7.7%, in conventional LP-TAE, respectively (P =0.003, P =0.000, P =0.006). Conclusion Segmental LP-TAE possesses stronger anticancerous effect and much less damage to liver function. Segmental LP-TAE is obviously superior than conventional LP-TAE in long term effectiveness.
