Expression and function of protease-activated receptor-2 on tumor cells
- VernacularTitle:蛋白酶激活受体-2在肿瘤细胞的表达及作用
- Author:
Wenxia SHI
;
Hong ZHOU
- Publication Type:Journal Article
- Keywords:
Cell line,tumor;
Peceptor,PAR-2
- From:
Cancer Research and Clinic
2008;20(9):646-648
- CountryChina
- Language:Chinese
-
Abstract:
Protease-activated receptor-2 (PAR-2) belongs to the receptor family which is coupled with G-protein. The N-terminus of PAR-2 is cleaved by some proteases to generate a new N-terminus. The new N-terminus can interact with and activate the receptor itself. The update research reported that PAR-2 could be expressed on some cancers as well as tumor cell lines. There are some relationships between the PAR-2 expression and the behaviors of tumor cell, such as proliferation, angiogenesis, migration and invasion.
