Monitoring of primary HIV-1 genotypic drug-resistance and HIV-1 subtype in 237 antiretroviral treatment-naive HIV/AIDS patients in China
- VernacularTitle:我国237例未接受抗病毒治疗的HIV/AIDS患者中原发性基因型耐药监测和病毒亚型分析
- Author:
Yang HAN
;
Jiqiu KUANG
;
Taisheng LI
;
Zhifeng QIU
;
Jing XIE
;
Lingyan ZUO
;
Yanling LI
;
Aixia WANG
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus(HIV);
Primary;
Drug resistance;
Protease;
Reverse transcriptase;
Subtype
- From:
Chinese Journal of Laboratory Medicine
2008;31(10):1095-1100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of primary HIV-1 genotype drug-resistance and viral subtype from 237 treatment-naive patients in China.nethods CD4+ T cell counts,plasma HIV-1 viral load and HIV-1 gene sequencing in total 237 treatment-naive patients enrolled from 20 provinces/regions were detected for the evaluation of primary HIV genotypic drug-resistance.Results The survey of 237 treatment-naive patients from muhicenter areas including Henan Province,Yunan Province,and Shanghai showed that 9 subtypes of HIV-1 strains were finally identified.Most of patients were infected before 2003.Only 3 cases had genotypic mutations associated resistance to antiretroviral drugs,with high resistance to nucleoside reverse transcriptase inhibitors(NRTIs),moderate resistance to protease inhibitors(PIs)and high resistance to non-nucleoside reverse transcriptase inhibitors(NNRTIs).respectively.The prevalence of primary genotypic drug resistance was 1.3%(3/237)in this study.Conclusions The rate of HIV-1 primary genotypic drug-resistance is still relatively low in treatment-naive HIV/AIDS patients while 9 subtypes of HIV-1 strain was diseovered.
