Function mechanism and research development of Skp2 in malignant tumors
- VernacularTitle:Skp2在恶性肿瘤中的作用机制和研究进展
- Author:
Chao XU
;
Zao JIANG
- Publication Type:Journal Article
- Keywords:
S-phase kinase-Associated proteins;
Neoplasms;
Prognosis
- From:
Cancer Research and Clinic
2008;20(10):715-718
- CountryChina
- Language:Chinese
-
Abstract:
Skp2 (S-phase kinase associated protein) is substrate recognition subunit of SCFSkp2 (Cul1-Rbx1-Skp1-F boxSkp2)complex,a kind of ubiquitin ligases (E3s). Skp2 involves in regulating many functions of cell,such as cell cycle progressing,cell proliferation and differentiation,as well as apoptosis.At present many studies indicated that Skp2 is closely related to tumorigenesis and prognosis.With deeper study of Skp2 in tumor, Skp2 has the potential to be a promising drug target and biomarker of prognosis in human cancer.
