Endoscopic submucosal dissection for early esophageal carcinomas and pre-malignant lesions
- VernacularTitle:内镜黏膜下剥离术治疗食管早期癌及癌前病变
- Author:
Pinghong ZHOU
;
Liqing YAO
;
Lili MA
;
Weifeng CHEN
;
Meidong XU
;
Yunshi ZHONG
;
Yiqun ZHANG
;
Xinyu QIN
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Endoscopy,gastrointestinal;
Endoscopic submucosal dissection
- From:
Chinese Journal of Digestive Endoscopy
2008;25(11):570-573
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the clinical application of endoscopic submucosal dissection(ESD) for early esophageal carcinomas and pre-malignant lesions. MethodsESD was performed for early esophageal carcinomas and intraepithelial neoplasms without submucosal infiltration. First, normal saline was injected into the submucosa to elevate the lesion from the muscle layer. Then, the surrounding mucosa of the lesion were cut, and the lesion was dissected along the connective tissue of the submucosa. ResultsOf 15 early esophageal carcinomas and intraepithelial neoplasms, ranging from 2.5 to 4.5 cm (mean size 3.2 cm) , 14 (93.3%) underwent ESD successfully . All 14 lesions were confirmed pathologically, and no basal or dissected margin was involved. The mean ESD procedure time (from fluid injection to complete dissection) was 75 min ( ranging from 45 to 150 min). Minor bleeding (mean volume 30 ml) occurred in all lesions, which was stopped by electric coagulation, argon plasma coagulation and clamps. No delayed bleeding occurred. The perforation rate of ESD was 0(0/15). Fourteen patients were followed up after ESD for 6 to 18 months (mean=11.5), and healed with no residue or recurrence. ConclusionESD is a novel endoscopic procedure to reseet early esophageal carcinomas and pre-malignant lesions, with which large lesions can be resected and pathological information can be provided.
