P2X3 receptor expression in DRG and bladder detrusor of an animal model of neurogenic bladder and ure-thra
- VernacularTitle:P2X3受体在神经源性膀胱大鼠背根神经节及逼尿肌中的表达
- Author:
Huiping ZHANG
;
Chengliang XIONG
;
Changhong ZHU
;
Zhong CHEN
;
Zhangqun YE
;
Guanghui DU
;
Yuan CHEN
;
Weifeng HU
;
Lijuan HU
;
Xiaoyong ZENG
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
P2X3 receptor;
Dorsl root ganglion;
Bladder detrusor
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(10):668-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the P2X3 receptor expression in L6-S1 dorsal root ganglion (DRG)and bladder detrusor in a rat model of neurogenic bladder and urethra. Methods Eighty Sprague-Dawley rats wererecruited and randomly divided into a sacral injury group, a suprasacral injury group and a control group. Spinal tran-section was performed to establish the animal model of neurogenic bladder and urethra in rats of the sacral injurygroup and suprasacral injury group. Check the P2X3 receptor expression in DBG and bladder detrusor among thethree groups by Western blot test at 20 days after model establishment. Results P2X3 receptor expression in L6-S1DRG of sacral injury group was significantly less than that of the suprasacral injury group, which was in turn signifi-cantly higher than that of the control group. P2X3 receptor expression in bladder detrusor of sacral injury group wassignificantly lower than that of the suprasacral injury group, which was in turn significantly higher than that of thecontrol group. Conclusion There was close relationship between P2X3 receptor expression and dysfunction of blad-der and urethra.
