Experimental study of the neurophysiological features of the animal model of acute cervical spinal cord com-pression
- VernacularTitle:颈脊髓急性压迫性损伤实验模型的神经电生理学分析
- Author:
Feng LIU
;
Haitao ZHU
;
Xincheng FAN
;
Mingping JIN
;
Li YANG
- Publication Type:Journal Article
- Keywords:
Cortical somatosensory evoked potential;
Motor evoked potential;
Spinal cord compression;
Animal model
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(10):671-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of its pathologic and neurophysiologic changes of a ani-mal model of cervical spinal cord compression, and to explore the relationship between the severity of spinal cord inju-ry and its functions. Methods Thirty-two rabbits were divided into 4 groups randomly. A catheter was inserted intothe vertebral canal and a balloon was inflated to compress spinal cord in epidural space. According to the diameter ofballoon, the animals were divided into 4 groups (A, B, C, D group), Each group consisted of 8 rabbits. The corti-cal somatosensory evoked potential (CSEP) and motor evoked potential (MEP) were used to assess neurologicalfunction. Motor function behavior was scored before and on 1, 3, 7 and 14 days after surgery. Histological observa-tions were performed, pathological changes were observed by light and electron microscope. Results Spinal cordcompression resulted in a gradual increase of the peak latency and significant decrease of the peak amplitude. The la-tency and amplitude of MEP were changed more dramatically than those of CSEP. The result indicated that MEP wasmore sensitive than CSEP to the compression. Analysis also revealed that the severer the pathologic changes, the lon-ger the latency and the lower the amplitude of the evoked potentials. Conclusion The animal model presented inthis paper was simple and standardized. Evoked potentials as a noninvasive technique have great value in monitoringspinal cord function. The variance of amplitude and the latency in significantly correlate with the degree of compres-sion of the spinal cord.
