Effects and implications of physical modalities on hs-CRP, TNF-α and adiponectin in patients with cerebral infarction
- VernacularTitle:物理因子治疗对脑梗死患者血清hs-CRP、TNF-α和脂联素的影响及其意义
- Author:
Xiaoyun YANG
;
Xiaomei WANG
;
Xin CHEN
;
Gan HOU
;
Ming YANG
- Publication Type:Journal Article
- Keywords:
Physical agents therapy;
Cerebral infarction;
hs-CRP;
TNF-α;
Adiponectin
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(10):692-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of physical agents therapy on serum hs-CRP, TNF-α andadiponectin in patients with cerebral infarction and the possible underlying mechanisms. Methods Sixty patientswith cerebral infarction were randomly and equally divided into two groups: 30 cases were treated with physical a-gents therapy ( physical therapy group) , and 30 with drugs only ( drug treated group). Thirty normal subjectsserved as the control group. The level of hs-CRP in the serum was determined by latex agglutination reaction, TNF-and adiponectin were determined by using ELISA before and after therapy. Results The levels of serum hs-CRP and TNF-α of patients with cerebral infarction before therapy were much higher than those of the control group,but adiponectin was significantly lower than those of the control group( P < 0.01 ). After therapy, the levels of ser-um hs-CRP and TNF-α were decreased and adiponectin was increased significantly in both treated groups ( P <0.01 ). Comparison with two treated groups showed that the levels of hs-CRP and TNF-α were lower and adiponec-tin was obviously higher in physical agents therapy group than those in the drug treated group ( P < 0.05 ). Con-clusion The patients with cerebral infarction have low level of serum adiponectin. Physical therapy might exertbeneficial effects on patients with cerebral infarction by the decreasing serum hs-CRP and TNF-α, as well as by ele-vating adiponectin.
