Study on the killer cell immunoglobulin-like receptor gene polymorphisms in leukemia patients and their siblings who have same HLA-A/B/DR typing
- VernacularTitle:白血病患者及其HLA-A/B/DR全相合同胞中杀伤细胞免疫球蛋白样受体基因型分布
- Author:
Yan ZHANG
;
Sheng LIU
;
Mengli LIU
;
Shihui YE
;
Bo WANG
;
Chunmei SHEN
;
Jun QI
- Publication Type:Journal Article
- Keywords:
Leukemia;
Killer cell immunoglobulin-like receptor;
Sibling
- From:
Chinese Journal of Microbiology and Immunology
2008;28(10):895-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between killer cell immunoglobulin-like receptors(KIR)and HLA by distribution of KIR gene in leukemia patients and their siblings who have same HLA-A/B/DR typing.Methods KIR genotypes were detected by PCR-SSP on 78 patients and their siblings who have same HLA-A/B/DR typing.Results There were 48.72%in 78 patients who had same KIR genotypes with their siblings while the 44.87%patients had different KIR genotypes with their siblings.There was no difference in frequency between patients and their siblings(P＞0.05).There were no differences in frequency among chronic myelocytic leukemia(CML),non acute lymphoblagtic leukemia(NALL)and acute lymphoblagtie leukemia(ALL)but the frequency of KIR2DS4 in CML was higher than others.Condusion The KIR gene and HLAⅠ antigen are heredity independently and relatively stable.The factor of disease has little effect on KIR gene.
