Endoscopic and pathologic findings in acute graft versus host disease after allogeneic bone marrow transplantation
- VernacularTitle:骨髓移植术后急性移植物抗宿主病的肠镜及病理表现
- Author:
Nan LI
;
Jianhua ZHU
;
Jun HUANG
;
Bing SHI
;
Lihui LIU
- Publication Type:Journal Article
- Keywords:
Graft versus host disease;
Acutedisease;
Enteritis;
Colonoscopy;
Pathology;
Grafting,bone marrow
- From:
Chinese Journal of Digestive Endoscopy
2008;25(9):458-461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the endoscopic and pathologic characters of acute graft versus host disease(aGVHD) after aUogeneie bone marrow transplantation.Methods The endoscopic and pathologic findings of 4 patients with acute aGVHD were retrospectively analyzed.Results The clinical manifestations of 4 patients were abdominal pain and diarrhea occurred 21～57 days after bone marrow transplantation.The eolonoseopy detected mucosa edema,erosion and multiple ulcers.The pathological findings included epithelial necrosis accompanied with infiltration of lympbocytes and plasmacytes,no cytomegalovirus was found in biopsies,and aGVHD was diagnosed.Three patients recovered after the treatment with corticosteroids,while the other one died.Conclusion The intestine is involved in aGVHD after allogeneie bone marrow transplantation,and the diagnosis depends on eolonoscopy and biopsy.
