Protective effect of pulsed magnetic field against cerebral ischemia-reperfusion injury in rats
- VernacularTitle:脉冲磁场对大鼠脑缺血再灌注损伤的保护作用
- Author:
Hongying WU
;
Ren LUO
;
Jianzhong FAN
;
Chuan LI
;
Yi WEI
- Publication Type:Journal Article
- Keywords:
Pulsed magnetic field;
Brain ischemia;
Reperfusion injury;
Insulin-like growth factor-1 (IGF-1)
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(11):742-744
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the neuroprotective effect of pulsed magnetic field in a animal focal cere-bral ischemica-reperfusion injury model. Methods Forty-eight Sprague-Dawley (SD) rats were randomized into 3 groups, a sham-operation group, a model group and a pulsed magnetic field group, with rats 16 in each group. Mid-dle cerebral artery occlusion (MCAO) method was employed to establish the focal cerebral ischemia-reperfusion inju-ry model in rats of model group and pulsed magnetic field group. Rats in sham-operation group was subject to the same operation procedure but not underwent ischemia-reperfusion. The infarction volume, histopathological damage and expressions of IGF-1 in ischemic brain tissue were investigated to evaluate the effect of pulsed magnetic field. Results The infarction volume was reduced, histopathological damage alleviated and expressions of IGF-1 in ische-mic brain tissue elevated in the pulsed magnetic field group as compared against the model group (P<0.05). Con-clusions Pulsed magnetic field might provide neuro-protection against cerebral ischemia-reperfusion injury.
