Expression of survivin in human dermal hemangioma and its relationship with caspase-3
- VernacularTitle:survivin在皮肤血管瘤组织中的表达及其与半胱氨酸天冬氨酸蛋白酶-3的关系
- Author:
Siyang LIU
;
Ling YE
;
Shengguo SHAN
;
Duanlian ZHANG
- Publication Type:Journal Article
- Keywords:
Survivin;
Caspase-3;
Hemangioma;
Immunohistochemistry
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2008;14(5):326-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of survivin and its relationship with that of caspase-3 in two stages of hemangioma and normal skin, and to explore the role of survivin in the patho-genesis of hemangioma. Methods A total of 50 cases of human dermal hemangioma and 8 eases of normal skin were analyzed for expression of survivin and caspase-3 by immunohistochemistry. Results The posi-tive ratio and average light density of survivin were obviously higher in proliferative hemangioma (0.2449±0.0135,0.7246±0.0747) than that in involutional hemangioma (0.1648±0.0217,0.5592±0.1601) and normal skin (0.1789±0.0126,0.4626±0.0961) (P<0.01). On the contrary, the expression of easpase-3 was up-regulated in involutional hemangioma (0.2386±0.0175, 0.4378±0.0593). Analysis of data also showed that there was a negative correlation between the average light density of survivin and caspase-3 (r=-0.95,P<0.01). Conclusions Survivin plays an important role in the pathogenesis of hemangioma and has a negative relationship with easpase-3.
