Studies of interaction between KIR alleles and the progression of HIV-1 infection in Chinese population
- VernacularTitle:中国HIV-1感染者KIR基因多态性与疾病进展关系的研究
- Author:
Dongbing XU
;
Xiaoxu HAN
;
Zining ZHANG
;
Min ZHANG
;
Di DAI
;
Bin ZHAO
;
Yanan WANG
;
Xiaoli ZHANG
;
Mingjia BAO
;
Hong SHANG
- Publication Type:Journal Article
- Keywords:
HIV-I;
Killer cell Ig-like receptors;
Polymerase chain reaction sequence-specific primers
- From:
Chinese Journal of Microbiology and Immunology
2008;28(12):1099-1102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the killer cell lg-like receptors (KIR) gene frequency of HIV-1 infected slow progressors(SP) and typical progressors(TP), and to analyze the interaction between KIR alleles and the progression of HIV-1 infection in Chinese population. Methods Eighty-one HIV-1 posi-tive individuals including 43 SPs and 38 TPs were recruited. Carriage of KIR genes was assessed using poly-merase chain reaction sequence-specific primers (PCR-SSP) assays. Results KIR2DS3 gene frequency was significantly lower in SP group (3.6%) than that in TP group (14.2%), P =0. 018 ,OR =0. 210,95% CI =0.053-0.833. The number of activating KIR genes was less in SP group than that in TP group, but was not significant (P = 0. 208). Conclusion Lower KIR2DS3 gene frequency may potentially be associated with slower progression to AIDS in Chinese population.
