Research for the protein tyrosine phosphatase nonreceptor 22 gene polymorphism in rheumatoid arthritis pafients
- VernacularTitle:类风湿关节炎患者蛋白酪氨酸磷酸酶非受体型22基因多态性的研究
- Author:
Xue FENG
;
Yongzhe LI
;
Rang ZHANG
;
Shumeng BAO
;
Dawei TONG
;
Shulan ZHANG
;
Chaojun HU
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Protein-tyrosine-phosphatose;
Polymorphism,single nucleotide
- From:
Chinese Journal of Laboratory Medicine
2008;31(12):1340-1343
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the PTPN22 gene polymorphism and rheumatoid arthritis(RA).Methods Real time fluorescent quantitation PCR was used to detect the 1123G＞C polymorphism of the PTPN22 gene from 200 RA patients,100 others rheumatic diseases and 200 the normal controls.The results were analyzed by SPSS 11.0 software.Results The CC genotype frequencies of RA patients.others rheumatic diseases and the normal controls were 0.120,0.020 and 0.015 respectively.There was a significant difiefence between BA patients and others rheumatic diseases (X=18.708.P＜0.01).1'here Wag a significant difference between RA patients and the normal controls(X2=24.337,P＜0.01).There was not statistically significant between others rheumatic diseases and the normal controls(X2=1.066,P＞0.05).The C allele frequency of RA patients,others rheumatic diseases and the normal controls were 0.360.0.190 and 0.215 respectively.The results were significant difference.Conclusion The PTPN22 gene could be one of predisposing genes and the therapeutic target genes with RA patients.
