The effect of treadmill training on metabotropic glutamate receptor of a rat model of middle cerebral artery occlusion
- VernacularTitle:运动训练对缺血再灌注大鼠纹状体中代谢型谷氨酸Ⅰ组受体基因表达的影响
- Author:
Xi ZHANG
;
Qingchuan GUO
;
Jie JIA
- Publication Type:Journal Article
- Keywords:
Exercise training;
Ischemia-reperfusion injury;
Glutamate;
Glutamate receptor
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2008;30(11):730-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of treadmill training on metabotropic glutamate receptor of a middle cerebral artery occlusion model in rat and its underlying mechanisms. Methods Sprague-Dawley male rats of 2 or 3 months old were randomly divided into 3 groups: a sham operation group, an iscbemia-reperfnsion group and a treadmill training group (subject to 2 weeks of training after the ischemia-reperfusion). All the animals were sacri-ficed after 2 weeks of training and their brains were sampled for measurement of the expression level of the striatum mGluR Ⅰ-mRNA, using RT-PCR technique. Results The striatum mRNA of mGluR1 and mGluR5 was signifi-cantly elevated in the ischemia-reperfusion group(P<0.01), but treadmill training significantly suppressed the ele-vation of the expression of mRNA of mGluR1 and mGluR5 (P<0.01). Conclusions Treadmill training can signif-icantly downregulate mGluR Ⅰ-mRNA expression. This might be one of the important mechanisms for inhibition of the excitatory glutamate production.
