Correlation between serum visfatin levels and gestational diabetes mellitus
- VernacularTitle:血清内脏脂肪素浓度与妊娠期糖尿病的关系
- Author:
Yan LIANG
;
Xianming XU
- Publication Type:Journal Article
- Keywords:
Cytokines;
Diabetes,gestational;
Insulin resistance;
Infant,newborn;
Birth weight
- From:
Chinese Journal of Perinatal Medicine
2008;11(6):369-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variations of serum levels of visfatin in pregnant women with different types of glucose intolerance and the associations with insulin resistance.metabolic parameters and newborn birth weight.Methods Totally,120 pregnant women in late trimester were divided into 3 groups according to the results of 50 g glucose challenge test(GCT)and 75 g oral glucose tolerance test:GDM group(n=45),GCT(+)group(n=20),and NGT group(n=55).Fasting levels of visfatin,insulin,total cholestrol and triglyceride were measured and the newborn birth weight was recorded.Results The serum visfatin level was significantly elevated in GDM group compared with the NGT group[(374.9±23.1)ng/ml vs(308.9±16.8)ng/ml,P＜0.05],but no significant difference was shown when compared with the GET(+)group[(346.5±23.1)ng/ml].Furthermore,serum visfatin levels had no relationship with insulin resistance,metabolic parameter and newbom birth weight.Conclusions Visfatin is elevated in GDM women and closely related with GDM,but not with insulin resistance,metabolic parameters and newborn birth weight.
