Advance research of histone deacetylase inhibitors in treatment of prostate cancer
10.3760/cma.j.issn.1673-4203.2011.01.009
- VernacularTitle:组蛋白去乙酰化抑制剂在前列腺癌临床治疗中的研究进展
- Author:
Bo FAN
;
Kaili ZHANG
;
Enzhong GUO
- Publication Type:Journal Article
- Keywords:
Histone acetylation;
Histone deacetylase inhibitors;
Prostatic neoplasms
- From:
International Journal of Surgery
2011;38(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
The imbalance between histone acetylation and histone deacetylation can lead to the inactivation of suppressor genes and the activation of oncogenes by influencing transcription. Based on this, researchers found that HDAC inhibitors can induce prostate cancer cells growth arrest, differentiation and apoptosis. This review summarizes the advance research of histone deacetylase inhibitors in treatment of prostate cancer.
