The role of CD40 in T cell-mediated immune response
10.3760/cma.j.issn.1673-4408.2011.01.015
- VernacularTitle:CD40在T细胞介导的免疫反应中的作用
- Author:
Kang LU
- Publication Type:Journal Article
- Keywords:
CD40;
T cells;
Costimulatory molecule
- From:
International Journal of Pediatrics
2011;38(1):41-43
- CountryChina
- Language:Chinese
-
Abstract:
The activation of CD40-CD40L costimulatory signal channel plays a necessary role in T cellmediated immune response. Activation of CD40 on antigen presenting cells by CD40L which expressed on Tlymphocytes, while contributing to the pro-in? ammatory response necessary for eradication of infection, accounts for the pathology in autoimmunity. Meanwhile, there is evidence that CD40 is also expressed on T-lymphocytes and can act as a costimulatory molecule. Further dissection of the exact nature and role of CD40 in T cell activation could lead the way to novel therapeutics for diseases which include organ-graft refection, autoimmune diseases,tumor, and inflammation.
