Comparison of two antibiotic prophylaxis schemes for the prevention of recurrent urinary tract infection in postmenopausal women
- VernacularTitle:两种抗生素用药方案预防绝经后女性复发性尿路感染的比较
- Author:
Yihong ZHONG
;
Yi FANG
;
Chensheng FU
;
Min YUAN
;
Jun JI
;
Jie TENG
;
Jianzhou ZOU
;
Xiaoqiang DING
- Publication Type:Journal Article
- Keywords:
Urethritis;
Recurrence;
Antibiotic prophylaxis
- From:
Chinese Journal of Nephrology
2008;24(12):865-867
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the efficacy and safety of intermittent patient-initiated single-dose antibiotic prophylaxis and continuous antibiotic prophylaxis for the prevention of recurrent urinary tract infection (UTI) in postmenopausal women. MethodsA randomized controlled clinical trial was conducted for the prevention of recurrent urinary tract infection. Single dose of antibiotic was given every night in continuous antibiotic prophylaxis group and every time after exposure to conditions predisposed to UTI in intermittent antibiotic prophylaxis group. The duration of prevention was 12 months in both groups. ResultsThe effective rates of intermittent antibiotic prophylaxis and continuous antibiotic prophylaxis were 71.0% and 81.8% respectively (P＞0.05). The incidence of gastrointestinal adverse reaction in intermittent antibiotic prophylaxis group was significantly lower than that in continuous antibiotic prophylaxis group (7.7% vs 28.6%,P＜0.05). ConclusionsCompared with continuous antibiotic prophylaxis, intermittent patient-initiated single-dose antibiotic prophylaxis is a better prophylaxis with less gastrointestinal adverse reactions for the prevention of recurrent urinary tract infection in postmenopausal women.
