The challenge of mass spectrometry-based proteomics in the clinical diagnosis
10.3760/cma.j.issn.1009-9158.2009.02.002
- VernacularTitle:基于质谱的蛋白质组学诊断所面临的挑战
- Author:
Ming GUAN
;
Weiwei LIU
;
Yuan Lü
- Publication Type:Journal Article
- Keywords:
Proteomics;
Mass spectrometry;
Blood chemical analysis
- From:
Chinese Journal of Laboratory Medicine
2009;32(2):130-133
- CountryChina
- Language:Chinese
-
Abstract:
Over the past several years, mass spectrometry technology has become the important method of choice for the discovery of new biomarkers.Because the features of mass spectrometry-based proteomics including sensitivity, high throughput, speed, combined with advanced bioinformatics allow for the rapid analysis of a bunch of proteins simultaneously.It has become a powerful laboratory tool in clinical study.However recent studies showed that critical comments were made on the poor reproducibility,statistical analysis of the data et al.This article focused on challenges of study design, mass spectrometry technology and biological relevance associated its application of mass spectrometry based proteomics in serum or plasma.
