The association of anticardiolipin antibody and protein C with portal vein thrombosis
10.3760/cma.j.issn.0254-1432.2009.01.010
- VernacularTitle:抗心磷脂抗体、蛋白C与肝硬化门静脉血栓的关系
- Author:
Donglei ZHANG
;
Jianyu HAO
;
Ning YANG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Anticardiolipin antibody;
Protein C;
Portal vein;
Thrombosis
- From:
Chinese Journal of Digestion
2009;29(1):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of anticardiolipin antibody(ACA) and protein C(PC) in cirrhotic patients with or without portal vein thrombosis(PVT). Methods During Jan. 2006 to Dec. 2007, 60 cirrhotic patients with (n=20) or without (n=40) PVT were analyzed. The concentrations of prothrombin time (PT), activited patial thromboplastin time (APTT), fibrogen, ACA and protein C (PC) were determined. Results The positive rate of ACA was 35% (7/20) in PVT group and 10% (4/40) in control group (P=0.045). The average level of ACA-IgG was significantly higher in PVT group [(10.15±5.31)U/ml] than that in control group [(6.70±3.75) U/ml]. The concentration of PC was significantly lower in PVT group [(2.47±0.62) mg/L] than that in control group [(2.93±0.88)mg/L]. No difference was found in APTT, levels of fibrogen and ACA-IgM between two groups. PT and APTT were progressively prolonged and fibrogen and PC were decreasing with the severity of Child-Pugh, respectively. The levels of ACA-IgG and ACA-IgM were increasing with the severity of Child-Pugh. Conclusions The coagulation and anticoagulation system is abnormal in patients with PVT who has higer ACA-IgG level and lower PC level. It is indicated that the ACA and PC may play an important role in formation of PVT.
