Association of polymorphisms of solute carrier family 22 member 4/5 genes with Crhon's disease in Chinese Han nationality

VernacularTitle:溶质载体家族22A4和5基因多态性与中国汉族人群克罗恩病的关联分析
Author: Yun FENG ; Kai WU ; Zhanjun LU ; Ping ZHENG
Publication Type:Journal Article
Keywords: Crhon's disease; Single nucleotide polymorphism; Case-control study
From: Chinese Journal of Digestion 2009;29(1):42-45
CountryChina
Language:Chinese
Abstract: Objective To study the association of single nucleotide polymorphisms (SNPs) of solute carrier family 22 member 4 (SLC22A4) and SLC22A5 genes with Crhon's disease (CD) in Chinese Han nationality. Methods SNPs in the entire coding region of SLC22A4 and SLC22A5 genes were screened by direct DNA sequencing in 80 CD patients and 80 healthy subjects, and statistical in Han population. Five SNPs were found in entire coding region (2 in SLC22A4 gene and 3 in distribution of the alleles and genotypes of SLC22A4 and SLC22A5 polymorphisms between CD patients and healthy controls. Conclusion There is no correlation of SLC22A4 and SLC22A5 with CD in Chinese Han nationality.