A primary study on the indexes change of coagulation and fibrinolysis in APL with ATRA and As2O3
- VernacularTitle:全反式维甲酸联合亚砷酸诱导治疗急性早幼粒细胞白血病凝血及纤溶指标改变的初步研究
- Author:
Yaqing FENG
;
Yongchun HE
;
Yanfang ZHANG
;
Lidong ZHANG
- Publication Type:Journal Article
- Keywords:
Leukemia,nonlymphocytic,acute;
Antineoplastic combined chemotherapy protocols;
Disseminated intravascular coagulation
- From:
Cancer Research and Clinic
2008;20(12):823-825
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the indexes change of coagulation and fibrinolysis in APL with ATRA and As2O3.Methods Treatment group 18 eases were undeaaked ATRA 20-30 mg/d until relieved completely.0.1%arsenic trioxide 10 ml with 5%glucose 500 ml for 28 days.Normal control 10 cases were undertaked ATRA 45～60 mg/d until relieved completely.Results The CR rate of treatment group was higher than control group(P＜0.05),the patients of control group showed different reactions such as thirsty mouth,rationale acid syndrome.2 cases reacted strongly and the treatment had to be interrupted,the patients of treatment group had little reaction,but liver function were badly hurt and liver-protection treatment was needed.Fbg,D-dimer recovery time is 7 days,21 days in treatment group,14 days,21 days in control group.Conclusion CR rate is high and has little side effect,and indexes change of coagulation and fibrinolysis were recovered quickly,it has great significance to take D-dimer as early diagnose and observe the indexes change during the treatment.
