Detection of urokinase-type plasminogen activator receptor and its clinical significance in cervical cancer

VernacularTitle:子宫颈癌患者血浆尿激酶受体检测及其意义
Author: Yongfeng GUO ; Shumin ZHENG
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Urinary plasminogen activator; Enzyme-linked immunosorbent assay
From: Cancer Research and Clinic 2008;20(12):829-831
CountryChina
Language:Chinese
Abstract: Objective To study the content of urokinase-type plasminogen activator receptor(uPAR)in the peripheral blood to investigate its value for the invasion metastasis and prognosis in cervical cancer.Methods The plasma level of suPAR in 30 normal women.94 patients with cervieal cancer was measured by using enzyme linked immunosorbent assay(ELISA).Results The mean level of suPAR was(0.5023±0.1724)ng/ml in plasma of 30 normal women,while that in plasma of 94 cervical cancer patients was (1.0433±0.2736)ng/ml.The plasma suPAR level of cervical cancer patients was increased in comparision with that of normal women (P＜0.01).The suPAR level in the cervieal cancer patients did not show a significant correlation with histological classification,histological grade,style of growth and tumor size(P＞0.05),but was related to clinical stage.lymphnode metastasis and depth of invasion (P＜0.05).Conclusion Plasma suPAR would be a more reliable and convenient indicator in monitoring uPA system,and could be widely used as a new tumor marker in clinic.