A clinical analysis of cervical cancer treatment with concurrent chemoradlation

VernacularTitle:同步放化疗治疗子宫颈癌的临床分析
Author: Xuefeng ZHAO
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Radiotherapy; Drug therapy; Prognosis
From: Cancer Research and Clinic 2009;21(1):26-28
CountryChina
Language:Chinese
Abstract: Objective To Compare the effect and side effect of middle and advanced cervical cancer between sensitizing chemotherapy and radiotherapy. Methods 65 cervical cancer patients were randomly divided into two set: treatment (33) and comparison (32). During radiotherapy, the treatment set was added two courses of sensitizing chemotherapy, where the first one began the first radiotherapy week and the second one began after four-to-six weeks. The chemotherapy scheme was PF. The comparison set only received radiotherapy. Results The short effective rate of treatment set and comparison set was 100 % and 91% respectively, and one year survival rate of them was 80 % and 66 %, two year 73 % and 31 %, the local recurrent rate 9 % and 31 %. Grade 3-4 acute leucopenia rate was 9 % and 13 %. The side effects of two sets were white blood cells decrease, radiation pmctitis and radiocystitis, and these results were similar. Conclusion The method of two cycles sensitizing chemotherapy during radiotherapy has better treatment effect for cervical cancer.