Expression of GLUT-1 glucose transporter in epithelial tumors of the ovary

VernacularTitle:葡萄糖转运蛋白1在卵巢浆液性肿瘤中的表达及其意义
Author: Shuli SHAO ; Lijuan YAN ; Yu CAI ; Quanhong WANG
Publication Type:Journal Article
Keywords: Glucose transport proteins,facilitative; Ovarian neoplasms; Neoplasms,cystic,mucinous and serous
From: Cancer Research and Clinic 2009;21(1):35-37
CountryChina
Language:Chinese
Abstract: Objective To evaluate the expression of the GLUT-1 glucose transporter in borderline and malignant epithelial neoplasms of the ovary. Methods Histologic sections of tumor tissues from 100 epithelial neoplasms of the ovary were stained for GLUT-1 using polyclonal GLUT-1 antibody and the labeled streptavidin procedure. Chi-square analysis was used to assess if their expression was associated with clinicopathoiogic characteristics of the tumors. Results Normal ovarian surface epithelial cell were either negative or weakly positive. The intensity of the stain was significantly stronger in malignant than borderline tumors (P<0.001). In malignant neoplasms, the intensity of the stain for GLUT-1 increased with histology. Conclusion Overexpression of the GLUT-1 transporter is associated with the histology and grade of the minors. These data suggest that the expression of this transporter may be closely related to the malignant transformation of epithelial ovarian tumors.