Research involved with 5-Fu metabolize and resistance mechanism
10.3760/cma.j.issn.1006-9801.2009.01.028
- VernacularTitle:5-氟尿嘧啶代谢及其耐药机制的研究进展
- Author:
Hua WANG
;
Jiafu JI
- Publication Type:Journal Article
- Keywords:
5-Fu;
Metabolism;
Drug resistance,neoplasm;
Research
- From:
Cancer Research and Clinic
2009;21(1):67-69
- CountryChina
- Language:Chinese
-
Abstract:
5-fluorouracil (5-Fu) as an antimetabolite drug,has been widely used in the treatment of various solid tumors.However, due to the heterogeneity of tumor and the impact of the individual, some patients still have drug resistance or serious lethal toxicity reaction.The text focuses on the research progress of pharmacogenomics and pharmacogenetics of some forecast elements which affect the efficacy and toxicity of 5-Fu,and discussed their guiding role on the choice of chemotherapy drugs.
