Mycophenolate mofetil combined with low dose prednisone in the treatment for adults with minimal change nephrotic syndrome and concomitant HBsAg positive
10.3760/cma.j.issn.1001-7097.2009.01.004
- VernacularTitle:吗替麦考酚酯联合低剂量激素治疗HBsAg阳性的成人微小病变性肾病综合征
- Author:
Xiayu LI
;
Jiong TIAN
;
Jianghua CHEN
;
Heng LI
;
Qiang HE
;
Weiqin LIN
;
Qin NI
;
Xuelin HE
;
Jianyong WU
- Publication Type:Journal Article
- Keywords:
Glucocorticoids;
Hepatitis B virus;
Nephrosis,lipoid;
Nephrotic syndrome;
Mycophenolate mofetil
- From:
Chinese Journal of Nephrology
2009;25(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the safety and efficacy of mycophenolate mofetil (MMF) combined with low dose corticosteroid in the treatment of adults with minimal change nephrotic syndrome and concomitant HBsAg positive (MCNS-HBsAg). Methods Thirty adults with MCNS-HBsAg were enrolled in this prospective study and were assigned to two groups. The MMF group (n=14) received low dose of prednisone combined with MMF (MMF 1.0 to 2.0 g/d patients of Pred group versus 35.7% patients of MMF group. 43.8% patients of Pred group versus 21.4% patients of MMF group received lamivudine therapy. Elevation of alanine aminotransferase(ALT) ocurred in 50% patients of Pred group and 28.6% patients of MMF group. The complete remission (CR) rate after 24 weeks treatment was 11/14 in Pred group versus 10/12 in MMF group. 6/11 patients of the Pred group and 4/10 patients of the MMF group who achieved CR experienced relapses during follow-up. Conclusions Use of MMF combined with low dose prednisone is as effective as conventional prednisone regimen in treating adults with MCNS-HBsAg. The MMF protocol seems to be superior in HBV reactivation to conventional prednisone protocol.
