Comparison on hematoxylin, cisplatin, hydroxycamptothecine and ather medicine in celiac chemotherapy for mice hepatoma (HepA) model and their inhibitory effect
10.3760/cma.j.issn.1006-9801.2009.02.004
- VernacularTitle:苏木精与顺铂、羟喜树碱等药物腹腔化疗对小鼠肝癌HepA细胞抑制作用的比较
- Author:
Liansheng REN
;
Hong ZHANG
;
Xihua BAI
;
Lei FAN
;
Yongming YANG
;
Na ZHAO
- Publication Type:Journal Article
- Keywords:
Hematoxylin;
Mitomycin;
Celiac cbemotherapy;
Mice;
HepA
- From:
Cancer Research and Clinic
2009;21(2):84-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the inhibitory effects to mice ascitic hepatoma (HepA) among hematoxylin,mitomycin,cisplatin,hydroxycamptothecine and other medicine in celiac chemotherapeutic route,probing into the credibility of hematoxylin in celiac chemotherapy.Methods Mice ascitic HepA model was set up by celiac inoculation of HepA strains.24 h after the inoculation,intraperitoneal administration was done,then raising the mice as routine.Their body weights were measured regularly,living quality observed,mean survival times compared among these groups.Having repeated the above experiment three tines,T/C values obtained in the three experiments were compared one another.Results The awerage survival time of mice of control group (inoculated but no medicine used) was 15.99-16.33 d; that of hematoxylin group was 36.35-39.81 d; that of mitomycin gro.up was 35.77-40.06 d; that of hydroxycamptothecine survived 20.79-38.47 d; and that of cisplatin group was 32.98-41.89 d.A comprehensive comparison showed that mitomycin group and hematoxylin group had better effects.Conclusion Hematoxylin in celiac chemotherapy has an outstanding effect to the mice's transplanted HepA,no significant difference with mitomycin.However,hydroxycamptothecine and cisplatin are not good enough.
