Effect of electrical stimulation of cerebellar fastigial nucleus on the contents of monoaminergic transmitters in frontal lobe of rats with depression
10.3760/cma.j.issn.0254-1424.2009.02.002
- VernacularTitle:电刺激小脑顶核对抑郁症大鼠额叶单胺类递质含量的影响
- Author:
Jing WU
;
Zhikuan DENG
- Publication Type:Journal Article
- Keywords:
Electrical stimulation;
Cerebellar fastigial nucleus;
Depression;
Monoaminergic transmit-ters;
Rat
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(2):78-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of electrical stimulation of cerebellar fastigial nucleus (FN) on the contents of monoaminergie transmitters in frontal lobes of rats with depression, and to explore the pathway and mechanism of electrical stimulation of cerebellum in treating depression. Methods A total of 30 Wistar rats were used tO establish the animal depression model by exposure to chronic stressing circumstances. Electrical stimulation delivered to the left cerebellar FN or left dentate nucleus (DN) for 1 h was used as the intervention. The contents of serotonin (5-HT), noradrenalin (NE) and dopamine (DA) in frontal lobe were determined with fluorospectropho-tometry. Results Compared with normal control group, the contents of 5-HT and NE in bilateral frontal lobes of depression model rats decreased significantly (P < 0. 001). No significant change of all three monoaminergic trans-mitters in normal rats was observed after stimulation of FN or DN (P > 0. 05), but significant increases of 5-HT and NE in right and left frontal lobes were observed in depression model rats after stimulation of FN (P < 0.05, P < 0.001; P <0.05, P <0.01), with the increase in right lobe more significant than in left lobes (P <0.05). In de-pression model rats underwent DN stimulation, significant increase of contents of all three monoaminergic transmitters in frontal lobes was observed. Conclusion ElectrieM stimulation of cerebellar FN can increase the contents of 5-HT and NE in frontal lobes of rats with depression, and this suggest that electrical stimulation might have therapeutic effect to depression.
