Functions of intracytoplasmic connexin in tumor progression
10.3760/cma.j.issn.1006-9801.2009.02.001
- VernacularTitle:细胞质内缝隙连接蛋白在肿瘤进展过程中的功能
- Author:
Yunlong GUO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Connexins;
Cell communication;
Protein transport;
Carcinoma,nepatocellular
- From:
Cancer Research and Clinic
2009;21(2):73-75
- CountryChina
- Language:Chinese
-
Abstract:
A considerable amount of evidence established that gap junctional intercellular communication (GJIC) suppresses tumor development by halting the stage of tumor promotion.Consistently,GJIC is downregulated in tumors.The downregulation of GJIC is caused by not only the reduced expression level of connexin proteins but also their aberrant cytoplasmic localization.Although it has been thought long that cytoplasmic localization of conncxin proteins is merely one of the mechanisms of the downregu]ation of GJIC,careful studies with human tumor samples indicated that the expression level of intracytoplasmic connexin proteins had different biological functions.
