Research progress of FHIT gene and its protein expression in the pathogenesis of lung cancer
10.3760/cma.j.issn.1006-9801.2009.02.026
- VernacularTitle:脆性组氨酸三联体基因及其表达蛋白在肺癌发病机制中的研究进展
- Author:
Mengjiao QIAN
;
Yunchao HUANG
- Publication Type:Journal Article
- Keywords:
FHIT gene;
Lung neoplasms;
Pathogenesis
- From:
Cancer Research and Clinic
2009;21(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Fragile histidine triad (FHIT) gene is an important tumor suppressor gene,in non-small-cell lung cancer and precancerous lesions its protein deficiency is common,reflecting the FHIT gene is changing in lung cancer occurred in the early molecular events.Ferredoxin in the participation of Fhit protein promotes the electron transport function,and promotes the apoptosis of tumour cells in oxidative stress environment.Fhit protein expression combined platinum enhanced the apoptosis of tumor cell response.With early occuring,high-frequency and facilitate detection,the abnormal changes of FHIT/FRA3B,which take great significance to explain the factors,such as race,genetic polymorphism,geography,environment,respiratory diseases in the pathogenesis of lung cancer.
