Variations of event-related potentials in senile depression and their dynamic changes after treatment
10.3760/cma.j.issn.0254-1424.2009.02.011
- VernacularTitle:老年期抑郁症患者事件相关电位变异及治疗前后动态变化
- Author:
Zaifu ZHANG
;
Weixing FAN
;
Ruoxiao HU
;
Zhirong YANG
;
Wangqiang LV
;
Jianwei ZHU
;
Xiaoqia JIANG
;
Xingshi CHEN
- Publication Type:Journal Article
- Keywords:
Senile depression;
Event related potentials;
P300;
Auditory evoked potential;
Brain-stem auditory evoked potential
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2009;31(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the features of event-related potentials (ERP) P300, auditory evoked potential(AEP) and brainstem auditory evoked potential(BAEP) in senile depression patients and the dynamic chan-ges before and after treatment of sertruline. Methods P300, AEP and BAEP were recorded in 31 senile depression patients using Chinese WOND 2000C Instrument, and a comparison between the patients and 33 normal controls in terms of these evoked potentials were made. Some of the depression patients treated with oral intake of sertraline were followed electophysiologically after 12 months of treatment. Results Compared with normal controls, senile depres-sion patients showed delay of latency of P300-P3 and BAEP-Ⅲ, decreased amplitude of P300-P3, AEP-P2 and BA-EP-Ⅲ(P <0.05 or 0.01). The 12-month follow-up measures of ERP showed significant improvement in terms of la-tency and amplitude of P3/P300,AEP-P2 and BAEP-Ⅲ after treatment of sertraline. Conclusion Senile depres-sion patients showed abnormality on several ERP indexes (such as P3/P300, AEP-P2 and BAEP-Ⅲ), and these in-dexes might provide important evidences to monitor the effect of medicine.
