Study of the correlation of integrin β1 and VEGF with invasion and metastasis of gastric carcinoma
10.3760/cma.j.issn.1006-9801.2009.02.009
- VernacularTitle:整合素β1、血管内皮生长因子与胃癌浸润转移的关系
- Author:
Ganting ZHAO
;
Xiaoliang ZHAO
;
Lingmin LI
;
Chunxuan JI
;
Peng XIAO
;
Qian ZHANG
;
Jinxia ZHANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Integrin β1;
Vascular endothelial growth factors;
Immunohistochemical method
- From:
Cancer Research and Clinic
2009;21(2):101-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of integrin β1 and VEGF in gastric carcinoma and evaluate its correlation with invasion and metastasis.Methods Immunohistochemistry techniques were used to study the expression of integrin β1 and VEGF in 63 gastric carcinoma specimens.We analyzed the variance with histological grade and stage and classification of clinical date.Results No significant relationship was observed among age,sex and histological classification of the expression of integrin β1 in the gastric cancer group (P>0.05).With the depth of invasion and lymphatic metastasis increasing,integrin β1 expression improved.The positive rate of integrin β1 among tubular adenocarcinoma,papillary carcinoma,mucinous carcinoma and undifferentiated carcinoma was 70.00 %,55.56 %,57.14 % and 64.86 %.No significant relationship was observed in it.Integrin β1 in cases with lymphnode metastasis was significantly higher than those without lymph node metastasis (P<0.05).No significant relationship was observed among VEGF expression and age,sex,histological classification and depth of invasion (P>0.05).Significant relationship was observed among VEGF expression and lymphatic metastasis.VECF in cases with lymph node metastasis was significantly higher than those without lymph node metastasis (P<0.05).Conclusion Immunohistochemistry techniques indicated that integrin β1 participated in the procession of invasion and metastasis.The expression of integrin β1 and VEGF are important factor,forecasting the invasion and metastasis.VEGF is an important factor for lymphnade metastasis of gastric carcinoma.VEGF in cases with lymphnode metastasis was significantly higher than those without lymphnode metastasis(P<0.05).The usage of integrin β1 and VEGF will improve the rightness in forecasting the invasion and lymph node metastasis of gastric carcinoma.
