Tumor suppressive properties of maspin and its expression levels in tumors
10.3760/cma.j.issn.1006-9801.2009.02.024
- VernacularTitle:Maspin在肿瘤中表达水平与抑瘤特性关系的研究进展
- Author:
Chunli DA
;
Yan XIN
- Publication Type:Journal Article
- Keywords:
Maspin;
Angiogenesis inhibitors;
Neoplasm metastasis
- From:
Cancer Research and Clinic
2009;21(2):135-137
- CountryChina
- Language:Chinese
-
Abstract:
Maspin (mammary serine protease inhibitor) is a kind of serpin.Many studies have characterized it as a tumor suppressor based on its ability to inhibit tumor angiogenesis,increase adhesion between tumor cells and ECM,inhibit tumor cell invasion and distant metastasis and promote apoptosis.In recent years,some studies have found maspin expresses high in some cancers,such as in mammary cancer and prostate cancer,while in some other cancers,such as in pancreatic cancer,maspin expression level shows high.The expression levels and biological functions of maspin in different organs still need further study.
