Status and role of p21cip1 for cancer biological therapy
10.3760/cma.j.issn.1006-9801.2009.03.027
- VernacularTitle:p21cip1在肿瘤生物治疗中的地位与作用
- Author:
Wenhu CHEN
;
Weimin MAO
- Publication Type:Journal Article
- Keywords:
p21cip1 gene;
Neoplasms;
Therapy
- From:
Cancer Research and Clinic
2009;21(3):212-215
- CountryChina
- Language:Chinese
-
Abstract:
Cancer is frequently considered to be a disease of cell cycle. Recently, it is reported that the transfer of functional ceil cycle regulators into caneer cells via vectors has the potential to intervene tumorigenesis development. This therapeutic strategy might allow cancer cells to regain missing or dysfunctional gene expression due to inhibiting aberrant proliferation or restoring phenotypes defects. As an important negative effecter of cell cycle progression, p21cip1 not only plays central roles in cell proliferation,differentiation, senescence and apoptosis, but also associates with tumor regression. In this review, we will mainly focus on discussing some recent progress in novel strategies for cancer biological therapy, related with the functions of p21cip1 in cell proliferation and apoptosis during tumorigenesis.
