Pingyangmycin in treatment of keloids:a clinical and experimental study

VernacularTitle:平阳霉素治疗瘢痕疙瘩的效果及组织学观察
Author: Jun CHEN ; Yunliang QIAN ; Jun YANG ; Danru WANG
Publication Type:Journal Article
Keywords: Pingyangmycin (bleomycin); Keloid; Injective therapy
From: Chinese Journal of Medical Aesthetics and Cosmetology 2009;15(2):110-113
CountryChina
Language:Chinese
Abstract: Objeetive To investigate the optimized concentration,effectiveness and histological change of Pingyangmycin by local injection of keloids for two weeks.Methods The appropriate concentration was analyzed,based on the Vancouver scar scale.48 eases of keloids were randomly divided into 4 groups with different concentrations of Pingyangmycin (1,0.5,0.25,and 0.125 mg/ml).Each case was iniected for five times at two weeks intervals,and then the statistical results (pair t test) and the histological changes were evaluated.Results Statistically,0.5 mg/ml group was more effective (P=0.0026),and this group had significant differences from the others (SNK test).The rate of the recurrence for one year was 12.00% in the whole effective cases.The keloid tissue after treatments,histologically,showed the thicker epidermis and larger papillary layer of the dermis,more inflammatory cells.Conclusions 0.5 mg/ml Pingyangmycin is the most appropriate concentration in this study and 0.25 mg/ml is the effective one.This treatment for keloid is convenient,safe,effective,low recrudescence and few side effects.