Evaluation of the application of modified glomerular filtration rate estimation equations in chronic kidney disease
10.3760/cma.j.issn.1001-7097.2009.03.001
- VernacularTitle:中国肾小球滤过率评估方程在慢性肾脏病患者的应用评价
- Author:
Xun LIU
;
Hua TANG
;
Ying TANG
;
Zhujiang CHEN
;
Hui PENG
;
Tanqi LOU
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Renal insufficiency,chronic;
Glomerular filtration rate;
Estimation equation
- From:
Chinese Journal of Nephrology
2009;25(3):165-169
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the applicability of modified formulas based on plasma creatinine levels in Chinese patients with chronic kidney disease (CKD). MethodsA total of 327 CKD patients were investigated. Glomerular filtration rate (GFR) was estimated with Chinese equations and Ruijin equation. The accuracy of estimated GFR was compared with 99mTc-DTPA-GFR (sGFR) in CKD patients. ResultsBland-Ahman analysis demonstrated that Ruijin equation was more consistent with sGFR than the other equations. But all the equations were not well consistent with sGFR. Linear regression showed that the slopes of Ruijin equation and MDRD-1 equation were closer to the identical line. 15%, 30% and 50% accuracy of Ruijin equation were higher than the other equations. But 30% accuracy of Ruijin equation was still less than 70%. When the accuracy of estimated GFRs was compared with sGFR in different stages of CKD, GFR estimated by Ruijin equation showed good results. ConclusionsWhen plasma creatinine is checked with enzymatic method, modified GFR estimation equations may show great bias in Chinese CKD patients. More clinical trails should be carried out to evaluate and identify the application of modified GFR estimation equations in Chinese patients with CKD.
